TMS 2023 Symposia

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Organizers: Jing Du, David Restrepo, Steven Naleway, Ning Zhang, Ling Li

Scope: The interaction of materials and biological systems is a rapidly growing, interdisciplinary frontier in materials science and engineering with boundless possibilities. Biological materials science involves the application of materials science and engineering principles to the study of biological materials, including the design, synthesis, and fabrication of materials systems from biological lessons. The Symposium on Biological Materials Science emphasizes the primacy of biological materials to the development of biomaterials and biomimetic materials. Biological materials comprise the inorganic and organic constituents of biological systems, whereas biomaterials are synthetic materials developed to replace, restore or augment biological materials. The structure and properties of biological materials exhibit a breadth and complexity unmatched in current biomaterials. Biological materials are formed under ambient conditions by living and adaptive biological systems for multifunctional performance. The structure and properties of biological materials are typically hierarchical, inhomogeneous, and anisotropic. Therefore, biological materials exhibit complex structure-property relationships which are only beginning to be elucidated. Biomimetic materials (or bioinspired materials) have unique, tailored structures and properties designed based upon the study of structure-property relationships in biological materials. Biomimetic materials most often utilize creative new methods of synthesis/processing and microstructure design in order to achieve the desired functionality.

Anticipated Number of Sessions: 6

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Organizers: Candan Tamerler, Kalpana Katti, Hannes Schniepp, Terry Lowe, Po-Yu Chen

Scope: The symposium focuses on fundamental understanding of biological and biomimetic solid interfaces as well as their implementation into engineering applications. Interfacing biological molecules predic tably with solid materials at the nanoscale is the key for hybrid materials design leading to innovative functional properties. Exploiting such properties towards developing functional materials and devices depends on a better understanding and control of the interfacial interactions at the atomic to nanoscale. This symposium will address the synthesis, modelling, and design principles of the bionano interfaces and their implementation into practical medical and technical applications such as tissue engineering, catalysis, sensors, electronics, and photonics. While the solids may include metals, ceramics, semiconductors, polymers, and their composites, the biopolymers include proteins, peptides, DNA, RNA, polysaccharides, glycans, lipids and membranes as well as cells and viruses. A special emphasis will be given to the assembly processes at solid liquid interfaces that lead to specific surface phenomena and designed bionano solid self-assembled structures and organizations towards functional materials, systems and devices.

The symposium will encompass the following themes, but are not limited to:

• Fundamentals on Bionano interfaces
• Biomimetic Approaches for Understanding and Designing Bio-Material Interfaces
• Surface phenomena: Dynamic interfacial interactions
• Abiotic and biotic interfaces
• Supramolecular self assembled systems
• Modelling the interactions at the bionano interfaces
• Multiscale mechanobiology and Biomechanics
• Nanoscale assembly rules and design criteria
• New trends in surface characterization, in situ and ex situ
• Predictive modelling and machine learning on biodesign and bioevaluations
• Biointerfaces and applications for sensing, electronics and photonics devices
• Biomolecular recognition of solids and bioactive interface design
• Protein corona effect on nanomaterials surfaces; Modulating toxicology
• Implementations in regenerative and restorative medicine

Anticipated Number of Sessions: 7

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Organizers: Bernd Gludovatz, Elizabeth Zimmermann, Steven Naleway

Scope: Biological tissues and materials self-assembled in nature have complex, hierarchical structures that can result in unique properties. These structure-property relationships are a wealth of information for materials scientists to explore for inspiration in designing the next generation of materials. Biological tissues and materials are, however, not always static entities. Often the dynamic structure is growing and/or adapting to the local biological or mechanical environment. Materials science investigations can offer great insight into how features in the multi-scale structure sense mechanical forces and biochemically promote adaptation. Materials-specific characterization techniques are then essential in quantifying the structure and related properties particularly for disease-related structural and functional modifications.

Topics that will be addressed:

• Mechanics and physiological adaptation of soft and hard tissues
• Role of the multi-scale structure in soft and hard tissue mechanics and adaptation
• Mechanobiology in tissues adaptation
• Mechanochemically active synthetic biomaterials
• Design of biomaterials to interact with tissue growth and adaptation

Anticipated Number of Sessions: 2

Organizers: Tolou Shokuhfar, Jing Du

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Scope: This symposium covers advances in new research directions for biomaterials for biomedical implants. It high- lights how researchers and clinicians are pushing the envelope in disease prevention, detection, and treatment. It covers more traditional areas such as hip, craniofacial, and spinal implants but also pushes us in new directions such as implantable sensors that can potentially determine changes in bone health and then respond to those changes to ensure strong healthy bones. It also emphasizes novel solutions to traditionally difficult tissue repair, such as meniscus repair and other organ tissue regeneration strategies. Most importantly, highlights the dynamic field of implant biomaterials as it introduces new chemistries to tissue regeneration, such as biodegradable metals and new polymers.

Anticipated Number of Sessions: 2

Organizers: Changxue Xu, Yifei Jin, Zhengyi Zhang, Jun Yin, Heqi Xu

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Biomaterials have been widely utilized in a variety of biomedical applications, such as tissue engineering, regenerative medicine, biosensors and medical implants, due to their inherent physical and chemical properties including biocompatibility, tunable mechanical properties and biodegradability, and hierarchical internal structures. Additive manufacturing, based on layer-by-layer fabrication mechanism, possesses critical advantages in fabrication of 3D structures of biomaterials for various biomedical applications, including complex geometries, heterogeneity, porosities, and incorporation of different growth factors. Typical 3D printing techniques used for biomaterials include inkjet printing, microextrusion, laser-assisted printing, stereolithography, to name a few. The most common biomaterials used in 3D printing are ceramics, polymers, and composites. The post-printing properties and microstructures are of great importance to the biomaterial functionality, such as mechanical properties, physical properties including swelling and degradation properties, pore size and porosity. The symposium shall focus on the recent advances in the biomaterials for 3D printing of scaffolds and tissues. Specific topics of interest include, but are not limited to:

• Design, fabrication and characterization of 3D tissue-engineered scaffolds
• Characterization of post-printing properties of biomaterials
• Modeling and simulation of biomaterial properties
• Fabrication of biomaterials-based heterogeneous structures
• Novel biomaterials and 3D printing techniques for scaffold fabrication
• Bioprinting of cellular structures and tissues
• Cell-biomaterial interaction
• Bioink rheological properties and printability
• Organ-on-chips

Sponsoring Committee: Materials Characterization Committee

Organizer: Henry A. Colorado

Number of Talks: 16

Sponsoring Committee: Advanced Characterization, Testing and Simulation Committee

Co-Sponsoring Committees: Alloy Phases Committee, Biomaterials Committee

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Organizers:

• Dr. Jinichiro Nakano (US-DOE National Energy Technology Laboratory, USA)
• Dr. David Alman (US-DOE National Energy Technology Laboratory, USA)
• Prof. Il Sohn (Yonsei University, South Korea)
• Prof. Hiroyuki Shibata (Tohoku University, Japan)
• Prof. Antoine Allanore (Massachusetts Institute of Technology, USA)
• Prof. Noritaka Saito (Kyushu University, Japan)
• Dr. Anna Nakano (US-DOE National Energy Technology Laboratory, USA)
• Prof. Zuotai Zhang (Southern University of Science and Technology, China)
• Prof. Candan Tamerler (University of Kansas, USA)
• Prof. Bryan Webler (Carnegie Mellon University, USA)
• Dr. Wangzhong Mu (KTH Royal Institute of Technology)
• Dr. David Veysset (Stanford University)
• Dr. Pranjal Nautiyal (University of Pennsylvania)

Scope: Real time observations can provide important information needed to understand materials behavior, as these techniques can provide temporal and spatial insights free from artifacts otherwise induced from conventional experimental techniques. Traditional and emerging advanced imaging techniques, which may be optical or non-optical, would allow such observations. Methods may be enhanced with capabilities that enable heating and cooling, controlled atmospheres, and application of stresses; and can be used to generate real time thermodynamic and kinetic data needed to study a variety of materials and processes. This symposium encompasses a broad range of materials science topics enabling cross-cutting opportunities for multiple disciplines (biomaterials, energy materials, functional materials, structural materials, etc.) while topics will be separately categorized in the technical program. Presentations are solicited on the application of these methods to materials science and industrial processes, as well as on development of such techniques.

Topics include, but not limited to:

• Studies using real time optical (e.g., visible light, white light, laser, IR, and UV) and non-optical (e.g., scanning probe, electron, and ultrasound) imaging techniques
• Researches using in-situ, in-operando, in-vitro, and in-vivo observation imaging techniques, such as thermal imaging furnace and other real time imaging methods
• Confocal techniques, including fluorescence and reflection types, which may be equipped with capabilities such as heating/cooling chambers, gas chambers, mechanical testing, Raman spectroscope, mass spectrometry, and FTIR
• Microscopic or telescopic imaging methods include hot thermocouple, resistance heating, and sessile drop techniques used for high temperature phenomena.
• Thermodynamic and kinetic data from these techniques, useful for phase diagram constructions, oxidation/corrosion modeling, phase formation kinetics studies, etc.
• Work using high speed and slow speed cameras
• Materials used in manufacturing real time imaging devices
• Novel technologies and methodologies for emerging imaging devices

The symposium plans to have joint sessions with:

• The Bio-Nano Interfaces and Engineering Applications symposium
• The Mechanical Response of Materials Investigated through Novel In-situ Experiments and Modeling symposium